CRK

CRK proto-oncogene, adaptor protein

This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008]

Member of: DE-2 DE-2.15

Biological processes 76 terms

SH2 domain binding (GO:0042169)SH3 domain binding (GO:0017124)actin cytoskeleton (GO:0015629)actin cytoskeleton organization (GO:0030036)cell adhesion (GO:0007155)cell migration (GO:0016477)cell population proliferation (GO:0008283)cellular response to endothelin (GO:1990859)cellular response to insulin-like growth factor stimulus (GO:1990314)cellular response to nerve growth factor stimulus (GO:1990090)cellular response to nitric oxide (GO:0071732)cellular response to transforming growth factor beta stimulus (GO:0071560)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoskeletal protein binding (GO:0008092)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)enzyme binding (GO:0019899)enzyme-linked receptor protein signaling pathway (GO:0007167)enzyme-linked receptor protein signaling pathway (GO:0007167)ephrin receptor signaling pathway (GO:0048013)extracellular exosome (GO:0070062)insulin-like growth factor receptor binding (GO:0005159)kinase binding (GO:0019900)membrane (GO:0016020)membrane (GO:0016020)negative regulation of cell motility (GO:2000146)negative regulation of cell motility (GO:2000146)negative regulation of natural killer cell mediated cytotoxicity (GO:0045953)negative regulation of wound healing (GO:0061045)negative regulation of wound healing (GO:0061045)neuromuscular junction (GO:0031594)nucleus (GO:0005634)phosphotyrosine residue binding (GO:0001784)phosphotyrosine residue binding (GO:0001784)plasma membrane (GO:0005886)positive regulation of JNK cascade (GO:0046330)positive regulation of Rac protein signal transduction (GO:0035022)positive regulation of cell growth (GO:0030307)positive regulation of smooth muscle cell migration (GO:0014911)positive regulation of substrate adhesion-dependent cell spreading (GO:1900026)positive regulation of substrate adhesion-dependent cell spreading (GO:1900026)postsynaptic specialization assembly (GO:0098698)protein binding (GO:0005515)protein domain specific binding (GO:0019904)protein localization to membrane (GO:0072657)protein phosphorylated amino acid binding (GO:0045309)protein phosphorylated amino acid binding (GO:0045309)protein tyrosine kinase binding (GO:1990782)protein tyrosine kinase binding (GO:1990782)protein-containing complex (GO:0032991)protein-macromolecule adaptor activity (GO:0030674)receptor tyrosine kinase binding (GO:0030971)regulation of Rac protein signal transduction (GO:0035020)regulation of actin cytoskeleton organization (GO:0032956)regulation of cell motility (GO:2000145)regulation of cell motility (GO:2000145)regulation of cell shape (GO:0008360)regulation of intracellular signal transduction (GO:1902531)regulation of intracellular signal transduction (GO:1902531)regulation of signal transduction (GO:0009966)regulation of transcription by RNA polymerase II (GO:0006357)regulation of wound healing (GO:0061041)response to cholecystokinin (GO:0061847)response to hepatocyte growth factor (GO:0035728)response to hydrogen peroxide (GO:0042542)response to peptide (GO:1901652)response to yeast (GO:0001878)scaffold protein binding (GO:0097110)signaling adaptor activity (GO:0035591)signaling adaptor activity (GO:0035591)signaling adaptor activity (GO:0035591)signaling receptor complex adaptor activity (GO:0030159)ubiquitin protein ligase binding (GO:0031625)

Expression (TPM)

TFs regulating CRK 0 TFs

Transcription factors with Perturb-seq knockdown data for CRK. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CRK upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to CRK

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CRK, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr17:1,179,265–1,180,687	276.2 kb	Distal (>10kb) Multiome	303
chr17:1,187,041–1,187,512	268.9 kb	Distal (>10kb) Multiome	361
chr17:1,202,976–1,204,162	252.8 kb	Distal (>10kb) Multiome	420
chr17:1,210,129–1,211,219	245.5 kb	Distal (>10kb) Multiome	35
chr17:1,268,002–1,268,635	187.9 kb	Distal (>10kb) Multiome	644
chr17:1,399,339–1,400,718	56.0 kb	Distal (>10kb) Multiome	879
chr17:1,455,335–1,456,916	127 bp	At TSS Multiome	879
chr17:1,484,963–1,486,119	29.1 kb	Distal (>10kb) Multiome	562
chr17:1,487,906–1,488,733	32.0 kb	Distal (>10kb) Multiome	597
chr17:1,490,717–1,492,156	35.3 kb	Distal (>10kb) Multiome	675
chr17:1,515,722–1,517,330	60.6 kb	Distal (>10kb) Multiome	796
chr17:1,562,314–1,563,047	106.6 kb	Distal (>10kb) Multiome	685
chr17:1,589,843–1,590,457	133.9 kb	Distal (>10kb) Multiome	538
chr17:1,627,811–1,629,617	172.5 kb	Distal (>10kb) Multiome	753
chr17:1,642,697–1,644,482	187.1 kb	Distal (>10kb) Multiome	467
chr17:1,648,163–1,650,244	192.9 kb	Distal (>10kb) Multiome	932
chr17:1,684,343–1,685,342	228.7 kb	Distal (>10kb) Multiome	728
chr17:1,710,017–1,710,765	254.2 kb	Distal (>10kb) Multiome	500
chr17:1,713,886–1,717,908	261.3 kb	Distal (>10kb) Multiome	1042
chr17:1,724,373–1,725,206	268.5 kb	Distal (>10kb) Multiome	720

Genome Browser

Genomic view of the CRK locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.