Transcription factors with Perturb-seq knockdown data for ENSG00000259986. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000259986 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000259986, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:82,910,611–82,911,202 | 268.2 kb | Distal (>10kb) Multiome | 35 | |
| chr15:82,952,161–82,953,316 | 226.4 kb | Distal (>10kb) Multiome | 430 | |
| chr15:82,985,830–82,986,497 | 193.0 kb | Distal (>10kb) Multiome | 853 | |
| chr15:83,010,925–83,012,341 | 167.5 kb | Distal (>10kb) Multiome | 964 | |
| chr15:83,066,587–83,067,782 | 111.9 kb | Distal (>10kb) Multiome | 877 | |
| chr15:83,106,916–83,108,096 | 71.8 kb | Distal (>10kb) Multiome | 392 | |
| chr15:83,143,995–83,145,038 | 34.9 kb | Distal (>10kb) Multiome | 146 | |
| chr15:83,178,492–83,178,687 | 493 bp | At TSS | 13 | |
| chr15:83,178,820–83,179,295 | 183 bp | At TSS Multiome | 114 | |
| chr15:83,206,651–83,208,545 | 29.0 kb | Distal (>10kb) Multiome | 607 | |
| chr15:83,378,916–83,379,702 | 200.1 kb | Distal (>10kb) Multiome | 191 | |
| chr15:83,446,671–83,448,301 | 268.1 kb | Distal (>10kb) Multiome | 542 |
Genomic view of the ENSG00000259986 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.