GNB1
G protein subunit beta 1

Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Member of: DE-2 DE-2.41
Biological processes 29 terms
G protein-coupled acetylcholine receptor signaling pathway (GO:0007213)G protein-coupled receptor signaling pathway (GO:0007186)G protein-coupled receptor signaling pathway (GO:0007186)GTPase activity (GO:0003924)GTPase activity (GO:0003924)GTPase binding (GO:0051020)Ras protein signal transduction (GO:0007265)adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)cellular response to catecholamine stimulus (GO:0071870)cellular response to prostaglandin E stimulus (GO:0071380)cytoplasm (GO:0005737)cytosol (GO:0005829)extracellular exosome (GO:0070062)extracellular vesicle (GO:1903561)heterotrimeric G-protein complex (GO:0005834)heterotrimeric G-protein complex (GO:0005834)heterotrimeric G-protein complex (GO:0005834)lysosomal membrane (GO:0005765)membrane (GO:0016020)photoreceptor disc membrane (GO:0097381)photoreceptor outer segment (GO:0001750)plasma membrane (GO:0005886)plasma membrane (GO:0005886)protein binding (GO:0005515)protein-containing complex binding (GO:0044877)signal transduction (GO:0007165)signal transduction (GO:0007165)signaling receptor complex adaptor activity (GO:0030159)synapse (GO:0045202)
Expression (TPM)
GNB1 — as a Regulated Gene

TFs regulating GNB1 0 TFs

Transcription factors with Perturb-seq knockdown data for GNB1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GNB1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to GNB1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GNB1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr1:1,599,945–1,600,642 291.1 kb Distal (>10kb) Multiome 307
chr1:1,615,103–1,616,799 275.6 kb Distal (>10kb) Multiome 951
chr1:1,628,379–1,632,529 261.0 kb Distal (>10kb) Multiome 552
chr1:1,658,722–1,659,418 232.0 kb Distal (>10kb) Multiome 602
chr1:1,724,054–1,724,738 166.7 kb Distal (>10kb) Multiome 631
chr1:1,777,637–1,780,173 112.4 kb Distal (>10kb) Multiome 970
chr1:1,782,008–1,783,229 108.8 kb Distal (>10kb) Multiome 590
chr1:1,883,184–1,883,831 7.5 kb Proximal (<10kb) Multiome 303
chr1:1,890,319–1,891,952 177 bp At TSS Multiome 748
chr1:1,908,308–1,910,312 18.1 kb Distal (>10kb) Multiome 801
chr1:1,918,258–1,920,500 28.3 kb Distal (>10kb) Multiome 820
chr1:1,959,901–1,960,517 69.1 kb Distal (>10kb) Multiome 594
chr1:2,019,137–2,019,982 128.4 kb Distal (>10kb) Multiome 288
chr1:2,044,569–2,045,304 153.9 kb Distal (>10kb) Multiome 403
chr1:2,049,277–2,050,992 159.2 kb Distal (>10kb) Multiome 732
chr1:2,132,340–2,134,100 242.3 kb Distal (>10kb) Multiome 508
chr1:2,189,382–2,190,314 298.6 kb Distal (>10kb) Multiome 719

Genome Browser

Genomic view of the GNB1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr1:1,589,945 – 2,200,314
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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