This gene is the host gene for the MIR17-92 cluster, a group of at least six microRNAs (miRNAs) that may be involved in cell survival, proliferation, differentiation, and angiogenesis. Amplification of this gene has been found in several lymphomas and solid tumors. Two non-protein coding transcript variants have been found for this host gene, but only the longest is a polycistronic transcript containing the MIR17-92 cluster. [provided by RefSeq, May 2012]
Transcription factors with Perturb-seq knockdown data for MIR17HG. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MIR17HG upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MIR17HG, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:91,217,001–91,217,945 | 131.7 kb | Distal (>10kb) Multiome | 179 | |
| chr13:91,346,886–91,349,419 | 1.6 kb | Proximal (<10kb) Multiome | 1086 | |
| chr13:91,355,494–91,355,685 | 6.4 kb | Proximal (<10kb) | 77 | |
| chr13:91,355,942–91,356,646 | 6.8 kb | Proximal (<10kb) | 91 | |
| chr13:91,356,761–91,357,559 | 7.6 kb | Proximal (<10kb) | 192 | |
| chr13:91,357,725–91,358,747 | 8.6 kb | Proximal (<10kb) | 170 | |
| chr13:91,358,859–91,359,737 | 9.7 kb | Proximal (<10kb) | 100 | |
| chr13:91,360,228–91,361,348 | 8.8 kb | Proximal (<10kb) | 90 | |
| chr13:91,398,265–91,399,827 | 49.5 kb | Distal (>10kb) Multiome | 446 |
Genomic view of the MIR17HG locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.