The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for HIPK1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HIPK1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HIPK1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:113,758,781–113,760,075 | 170.2 kb | Distal (>10kb) Multiome | 889 | |
| chr1:113,811,244–113,812,738 | 117.3 kb | Distal (>10kb) Multiome | 978 | |
| chr1:113,904,394–113,905,850 | 24.6 kb | Distal (>10kb) Multiome | 1025 | |
| chr1:113,929,054–113,930,528 | 119 bp | At TSS Multiome | 1003 | |
| chr1:113,938,331–113,938,852 | 8.8 kb | Proximal (<10kb) Multiome | 26 | |
| chr1:113,978,866–113,979,713 | 49.6 kb | Distal (>10kb) Multiome | 426 | |
| chr1:113,999,654–114,000,118 | 70.2 kb | Distal (>10kb) Multiome | 40 | |
| chr1:114,031,872–114,032,790 | 102.5 kb | Distal (>10kb) Multiome | 88 | |
| chr1:114,037,114–114,037,804 | 107.6 kb | Distal (>10kb) Multiome | 57 | |
| chr1:114,080,406–114,081,350 | 151.0 kb | Distal (>10kb) Multiome | 200 | |
| chr1:114,152,319–114,153,141 | 223.0 kb | Distal (>10kb) Multiome | 229 |
Genomic view of the HIPK1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.