Enables histone H3K36 demethylase activity and histone H3K9me2/H3K9me3 demethylase activity. Predicted to be involved in brain development; chromatin remodeling; and regulation of gene expression. Located in cytosol and nucleoplasm. Implicated in autosomal dominant intellectual developmental disorder 65; breast cancer; colorectal cancer; malignant peripheral nerve sheath tumor; and stomach cancer. Biomarker of several diseases, including alopecia areata; lung cancer; medulloblastoma; prostate cancer; and stomach cancer. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for KDM4B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KDM4B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KDM4B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:4,669,686–4,671,221 | 298.7 kb | Distal (>10kb) Multiome | 797 | |
| chr19:4,678,652–4,679,681 | 289.9 kb | Distal (>10kb) Multiome | 164 | |
| chr19:4,723,373–4,724,832 | 245.2 kb | Distal (>10kb) Multiome | 1021 | |
| chr19:4,791,166–4,792,360 | 177.6 kb | Distal (>10kb) Multiome | 897 | |
| chr19:4,867,260–4,868,220 | 101.4 kb | Distal (>10kb) Multiome | 718 | |
| chr19:4,908,827–4,910,489 | 59.1 kb | Distal (>10kb) Multiome | 766 | |
| chr19:4,968,227–4,969,595 | 229 bp | At TSS Multiome | 764 | |
| chr19:4,971,166–4,971,575 | 2.0 kb | Proximal (<10kb) | 241 | |
| chr19:5,048,124–5,048,589 | 79.3 kb | Distal (>10kb) Multiome | 444 |
Genomic view of the KDM4B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.