The protein encoded by this gene is a member of the CMGC family of serine/threonine protein kinases. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Altered expression of this gene has been observed in multiple human cancers. A mutation in this gene resulting in reduced cell proliferation, and impaired cell motility and polarity, and has been identified in patients with primary microcephaly. [provided by RefSeq, Aug 2017]
Transcription factors with Perturb-seq knockdown data for CDK6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CDK6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CDK6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:92,589,648–92,590,940 | 246.3 kb | Distal (>10kb) Multiome HiCAR | 1025 | |
| chr7:92,608,546–92,609,216 | 227.7 kb | Distal (>10kb) Multiome HiCAR | 301 | |
| chr7:92,763,629–92,764,462 | 72.6 kb | Distal (>10kb) Multiome | 433 | |
| chr7:92,832,617–92,837,194 | 2.6 kb | Proximal (<10kb) Multiome | 1121 | |
| chr7:92,840,359–92,840,625 | 3.8 kb | Proximal (<10kb) | 28 | |
| chr7:92,848,440–92,849,238 | 12.1 kb | Distal (>10kb) Multiome | 136 | |
| chr7:92,880,092–92,880,930 | 44.0 kb | Distal (>10kb) Multiome | 192 | |
| chr7:92,925,995–92,927,027 | 90.0 kb | Distal (>10kb) Multiome | 201 | |
| chr7:93,006,288–93,007,025 | 170.0 kb | Distal (>10kb) Multiome | 128 | |
| chr7:93,043,277–93,044,576 | 207.1 kb | Distal (>10kb) Multiome | 356 |
Genomic view of the CDK6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.