This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Several alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2010]
Transcription factors with Perturb-seq knockdown data for ADAM9. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ADAM9 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ADAM9, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:38,704,269–38,704,886 | 292.2 kb | Distal (>10kb) Multiome | 37 | |
| chr8:38,734,447–38,735,152 | 262.0 kb | Distal (>10kb) Multiome | 738 | |
| chr8:38,756,730–38,757,722 | 239.8 kb | Distal (>10kb) Multiome | 535 | |
| chr8:38,770,080–38,770,606 | 226.5 kb | Distal (>10kb) Multiome | 340 | |
| chr8:38,786,808–38,788,320 | 209.6 kb | Distal (>10kb) Multiome | 620 | |
| chr8:38,899,958–38,902,158 | 95.3 kb | Distal (>10kb) Multiome | 565 | |
| chr8:38,973,978–38,975,173 | 22.2 kb | Distal (>10kb) Multiome | 205 | |
| chr8:38,995,870–38,997,751 | 34 bp | At TSS Multiome | 913 | |
| chr8:39,004,744–39,005,067 | 8.0 kb | Proximal (<10kb) | 74 | |
| chr8:39,029,145–39,029,788 | 32.6 kb | Distal (>10kb) Multiome | 74 |
Genomic view of the ADAM9 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.