Predicted to enable symporter activity. Involved in bone development; heparin proteoglycan biosynthetic process; and intracellular calcium ion homeostasis. Located in Golgi apparatus; endoplasmic reticulum; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SLC10A7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC10A7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC10A7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:146,243,313–146,244,097 | 278.2 kb | Distal (>10kb) Multiome | 248 | |
| chr4:146,521,232–146,523,112 | 161 bp | At TSS Multiome | 826 | |
| chr4:146,637,802–146,639,468 | 117.0 kb | Distal (>10kb) Multiome | 313 | |
| chr4:146,647,528–146,648,929 | 126.6 kb | Distal (>10kb) Multiome | 297 | |
| chr4:146,654,496–146,655,708 | 133.3 kb | Distal (>10kb) Multiome | 371 |
Genomic view of the SLC10A7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.