This gene encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation, and erythroid differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
Transcription factors with Perturb-seq knockdown data for LYN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LYN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LYN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:55,772,095–55,773,951 | 106.6 kb | Distal (>10kb) Multiome | 1008 | |
| chr8:55,845,049–55,845,422 | 34.6 kb | Distal (>10kb) Multiome | 105 | |
| chr8:55,847,706–55,848,605 | 31.7 kb | Distal (>10kb) Multiome | 406 | |
| chr8:55,878,876–55,880,971 | 5 bp | At TSS Multiome | 747 | |
| chr8:55,919,468–55,920,026 | 40.0 kb | Distal (>10kb) Multiome | 374 | |
| chr8:56,073,616–56,075,349 | 194.7 kb | Distal (>10kb) Multiome | 1070 | |
| chr8:56,156,925–56,157,710 | 277.5 kb | Distal (>10kb) Multiome | 251 |
Genomic view of the LYN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.