The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for AATF. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AATF upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AATF, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:36,600,997–36,602,715 | 347.4 kb | Distal (>10kb) Multiome HiCAR | 823 | |
| chr17:36,657,825–36,658,420 | 290.9 kb | Distal (>10kb) Multiome | 220 | |
| chr17:36,722,258–36,722,869 | 226.5 kb | Distal (>10kb) Multiome | 428 | |
| chr17:36,727,484–36,729,207 | 220.6 kb | Distal (>10kb) Multiome | 373 | |
| chr17:36,742,321–36,742,786 | 206.4 kb | Distal (>10kb) Multiome | 38 | |
| chr17:36,808,179–36,808,595 | 140.6 kb | Distal (>10kb) Multiome | 138 | |
| chr17:36,846,879–36,848,731 | 100.6 kb | Distal (>10kb) Multiome | 163 | |
| chr17:36,849,720–36,850,483 | 98.9 kb | Distal (>10kb) Multiome | 281 | |
| chr17:36,862,044–36,863,068 | 86.3 kb | Distal (>10kb) Multiome | 192 | |
| chr17:36,880,130–36,880,730 | 68.5 kb | Distal (>10kb) Multiome | 47 | |
| chr17:36,884,535–36,886,092 | 63.5 kb | Distal (>10kb) Multiome | 169 | |
| chr17:36,920,793–36,921,793 | 27.6 kb | Distal (>10kb) Multiome | 301 | |
| chr17:36,935,552–36,937,008 | 12.3 kb | Distal (>10kb) Multiome | 360 | |
| chr17:36,941,980–36,942,525 | 6.4 kb | Proximal (<10kb) | 72 | |
| chr17:36,945,816–36,946,730 | 2.2 kb | Proximal (<10kb) | 60 | |
| chr17:36,947,533–36,949,544 | 1.1 kb | Proximal (<10kb) Multiome | 992 | |
| chr17:37,124,503–37,125,029 | 175.7 kb | Distal (>10kb) Multiome | 41 |
Genomic view of the AATF locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.