This gene encodes a protein containing RING-type and C3H1-type zinc finger motifs. The encoded protein recognizes and binds to a constitutive decay element (CDE) in the 3' UTR of mRNAs, leading to mRNA deadenylation and degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Transcription factors with Perturb-seq knockdown data for RC3H1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RC3H1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RC3H1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:173,824,030–173,825,369 | 197.8 kb | Distal (>10kb) Multiome | 904 | |
| chr1:173,852,512–173,853,711 | 169.3 kb | Distal (>10kb) Multiome | 358 | |
| chr1:173,859,027–173,863,516 | 159.7 kb | Distal (>10kb) Multiome | 578 | |
| chr1:173,866,947–173,869,294 | 154.0 kb | Distal (>10kb) Multiome | 1182 | |
| chr1:174,021,545–174,024,235 | 18 bp | At TSS Multiome | 1001 | |
| chr1:174,158,556–174,160,514 | 137.1 kb | Distal (>10kb) Multiome | 924 |
Genomic view of the RC3H1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.