AXIN1

axin 1 | PPP1R49

This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Member of: DE-2 DE-2.12

Biological processes 81 terms

I-SMAD binding (GO:0070411)I-SMAD binding (GO:0070411)I-SMAD binding (GO:0070411)R-SMAD binding (GO:0070412)SMAD binding (GO:0046332)Wnt signalosome (GO:1990909)armadillo repeat domain binding (GO:0070016)beta-catenin binding (GO:0008013)beta-catenin binding (GO:0008013)beta-catenin binding (GO:0008013)beta-catenin binding (GO:0008013)beta-catenin destruction complex (GO:0030877)beta-catenin destruction complex (GO:0030877)beta-catenin destruction complex (GO:0030877)beta-catenin destruction complex assembly (GO:1904885)cell cortex (GO:0005938)cell development (GO:0048468)cell periphery (GO:0071944)cellular response to glucose starvation (GO:0042149)cellular response to glucose starvation (GO:0042149)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasmic vesicle (GO:0031410)cytoplasmic vesicle (GO:0031410)cytosol (GO:0005829)enzyme binding (GO:0019899)identical protein binding (GO:0042802)identical protein binding (GO:0042802)identical protein binding (GO:0042802)identical protein binding (GO:0042802)late endosome (GO:0005770)late endosome (GO:0005770)lateral plasma membrane (GO:0016328)membrane (GO:0016020)microtubule cytoskeleton (GO:0015630)molecular adaptor activity (GO:0060090)molecular adaptor activity (GO:0060090)negative regulation of TORC1 signaling (GO:1904262)negative regulation of Wnt signaling pathway (GO:0030178)negative regulation of canonical Wnt signaling pathway (GO:0090090)negative regulation of canonical Wnt signaling pathway (GO:0090090)negative regulation of canonical Wnt signaling pathway (GO:0090090)negative regulation of canonical Wnt signaling pathway (GO:0090090)negative regulation of canonical Wnt signaling pathway (GO:0090090)nucleolus (GO:0005730)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)p53 binding (GO:0002039)perinuclear region of cytoplasm (GO:0048471)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of JNK cascade (GO:0046330)positive regulation of JNK cascade (GO:0046330)positive regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032436)positive regulation of protein catabolic process (GO:0045732)positive regulation of protein catabolic process (GO:0045732)positive regulation of protein ubiquitination (GO:0031398)positive regulation of ubiquitin-dependent protein catabolic process (GO:2000060)proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)protein binding (GO:0005515)protein domain specific binding (GO:0019904)protein homodimerization activity (GO:0042803)protein homodimerization activity (GO:0042803)protein kinase binding (GO:0019901)protein kinase binding (GO:0019901)protein kinase binding (GO:0019901)protein serine/threonine kinase activator activity (GO:0043539)protein serine/threonine kinase binding (GO:0120283)protein-containing complex (GO:0032991)protein-containing complex assembly (GO:0065003)protein-macromolecule adaptor activity (GO:0030674)protein-macromolecule adaptor activity (GO:0030674)signaling adaptor activity (GO:0035591)signaling adaptor activity (GO:0035591)ubiquitin protein ligase binding (GO:0031625)ubiquitin protein ligase binding (GO:0031625)ubiquitin protein ligase binding (GO:0031625)ubiquitin-like ligase-substrate adaptor activity (GO:1990756)ubiquitin-like ligase-substrate adaptor activity (GO:1990756)

Expression (TPM)

TFs regulating AXIN1 0 TFs

Transcription factors with Perturb-seq knockdown data for AXIN1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AXIN1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to AXIN1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AXIN1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr16:52,954–54,208	299.0 kb	Distal (>10kb) Multiome	950
chr16:71,378–73,062	281.2 kb	Distal (>10kb) Multiome	639
chr16:77,240–78,636	274.6 kb	Distal (>10kb) Multiome	685
chr16:138,551–139,186	214.1 kb	Distal (>10kb) Multiome	674
chr16:164,983–166,147	187.6 kb	Distal (>10kb) Multiome	234
chr16:180,313–181,713	171.2 kb	Distal (>10kb) Multiome	994
chr16:228,869–229,598	123.4 kb	Distal (>10kb) Multiome	1035
chr16:234,152–235,669	117.9 kb	Distal (>10kb) Multiome	908
chr16:351,804–354,436	214 bp	At TSS Multiome	654
chr16:378,999–379,813	26.6 kb	Distal (>10kb) Multiome	225
chr16:380,836–382,614	29.3 kb	Distal (>10kb) Multiome	634
chr16:383,438–384,218	31.1 kb	Distal (>10kb) Multiome	342
chr16:396,893–397,640	44.8 kb	Distal (>10kb) Multiome	496
chr16:401,380–402,199	49.1 kb	Distal (>10kb) Multiome	818
chr16:424,888–426,136	72.9 kb	Distal (>10kb) Multiome	752
chr16:483,333–484,000	131.0 kb	Distal (>10kb) Multiome	143
chr16:526,749–528,601	174.9 kb	Distal (>10kb) Multiome	811
chr16:569,530–570,338	217.1 kb	Distal (>10kb) Multiome	492
chr16:578,896–579,353	226.4 kb	Distal (>10kb) Multiome	511
chr16:588,593–590,724	237.2 kb	Distal (>10kb) Multiome	853
chr16:635,900–638,127	283.6 kb	Distal (>10kb) Multiome	1021
chr16:641,491–643,007	289.1 kb	Distal (>10kb) Multiome	856
chr16:648,795–649,829	296.6 kb	Distal (>10kb) Multiome	862

Genome Browser

Genomic view of the AXIN1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.