This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Overexpression of this gene was shown to induce cell apoptosis. It uses multiple polyadenylation sites. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for DAPK2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DAPK2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DAPK2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:63,833,277–63,834,519 | 212.5 kb | Distal (>10kb) Multiome | 873 | |
| chr15:64,045,892–64,046,997 | 36 bp | At TSS Multiome | 442 | |
| chr15:64,093,386–64,094,387 | 47.5 kb | Distal (>10kb) Multiome | 765 | |
| chr15:64,095,741–64,096,612 | 49.5 kb | Distal (>10kb) Multiome | 839 | |
| chr15:64,146,930–64,147,642 | 100.7 kb | Distal (>10kb) Multiome | 403 | |
| chr15:64,151,111–64,152,828 | 105.2 kb | Distal (>10kb) Multiome | 586 | |
| chr15:64,152,948–64,154,154 | 107.2 kb | Distal (>10kb) Multiome | 593 | |
| chr15:64,162,530–64,163,834 | 116.7 kb | Distal (>10kb) Multiome | 876 |
Genomic view of the DAPK2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.