This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PPP1R13B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPP1R13B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPP1R13B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:103,561,982–103,563,356 | 284.8 kb | Distal (>10kb) Multiome | 781 | |
| chr14:103,628,110–103,630,126 | 218.4 kb | Distal (>10kb) Multiome | 909 | |
| chr14:103,715,029–103,716,504 | 132.0 kb | Distal (>10kb) Multiome | 709 | |
| chr14:103,846,809–103,848,686 | 107 bp | At TSS Multiome | 711 | |
| chr14:103,855,145–103,855,758 | 8.0 kb | Proximal (<10kb) Multiome | 418 | |
| chr14:103,871,719–103,872,659 | 24.5 kb | Distal (>10kb) Multiome | 313 | |
| chr14:103,910,266–103,910,793 | 62.9 kb | Distal (>10kb) Multiome | 374 | |
| chr14:103,921,195–103,921,889 | 74.0 kb | Distal (>10kb) Multiome | 874 | |
| chr14:104,136,029–104,136,725 | 288.7 kb | Distal (>10kb) Multiome | 125 | |
| chr14:104,137,362–104,139,355 | 290.1 kb | Distal (>10kb) Multiome | 605 |
Genomic view of the PPP1R13B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.