This gene encodes a membrane protein belonging to the interleukin-17 receptor (IL-17R) protein family. The encoded protein is a component of the interleukin-17 receptor signaling complex, and the interaction between this protein and IL-17R does not require the interleukin. The gene product also affects fibroblast growth factor signaling, inhibiting or stimulating growth through MAPK/ERK signaling. Alternate splicing generates multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016]
Transcription factors with Perturb-seq knockdown data for IL17RD. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IL17RD upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IL17RD, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:56,874,031–56,874,571 | 290.9 kb | Distal (>10kb) Multiome | 83 | |
| chr3:57,078,355–57,079,870 | 86.1 kb | Distal (>10kb) Multiome | 674 | |
| chr3:57,130,457–57,131,979 | 34.4 kb | Distal (>10kb) Multiome | 353 | |
| chr3:57,158,954–57,159,929 | 6.0 kb | Proximal (<10kb) Multiome | 259 | |
| chr3:57,160,383–57,161,092 | 4.6 kb | Proximal (<10kb) Multiome | 147 | |
| chr3:57,164,404–57,166,039 | 43 bp | At TSS Multiome | 455 | |
| chr3:57,169,032–57,169,420 | 3.7 kb | Proximal (<10kb) | 25 | |
| chr3:57,169,750–57,170,529 | 4.9 kb | Proximal (<10kb) Multiome | 491 | |
| chr3:57,194,399–57,195,064 | 29.5 kb | Distal (>10kb) Multiome | 31 | |
| chr3:57,199,761–57,200,263 | 34.7 kb | Distal (>10kb) Multiome | 256 | |
| chr3:57,227,073–57,228,173 | 62.4 kb | Distal (>10kb) Multiome HiCAR | 859 |
Genomic view of the IL17RD locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.