The adiponectin receptors, ADIPOR1 (MIM 607945) and ADIPOR2, serve as receptors for globular and full-length adiponectin (MIM 605441) and mediate increased AMPK (see MIM 602739) and PPAR-alpha (PPARA; MIM 170998) ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin (Yamauchi et al., 2003 [PubMed 12802337]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for ADIPOR2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ADIPOR2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ADIPOR2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:1,489,149–1,489,771 | 201.7 kb | Distal (>10kb) Multiome | 84 | |
| chr12:1,529,777–1,531,495 | 160.7 kb | Distal (>10kb) Multiome | 301 | |
| chr12:1,580,606–1,581,311 | 110.2 kb | Distal (>10kb) Multiome | 62 | |
| chr12:1,593,421–1,595,263 | 96.3 kb | Distal (>10kb) Multiome | 819 | |
| chr12:1,605,298–1,605,729 | 85.6 kb | Distal (>10kb) Multiome | 565 | |
| chr12:1,629,192–1,630,785 | 61.3 kb | Distal (>10kb) Multiome | 357 | |
| chr12:1,642,503–1,643,018 | 48.2 kb | Distal (>10kb) Multiome | 36 | |
| chr12:1,661,496–1,662,312 | 29.2 kb | Distal (>10kb) Multiome | 689 | |
| chr12:1,662,725–1,663,523 | 27.9 kb | Distal (>10kb) Multiome | 433 | |
| chr12:1,690,560–1,691,733 | 48 bp | At TSS Multiome | 863 | |
| chr12:1,720,538–1,721,023 | 29.7 kb | Distal (>10kb) Multiome | 64 | |
| chr12:1,794,646–1,795,302 | 103.8 kb | Distal (>10kb) Multiome | 100 | |
| chr12:1,795,674–1,796,431 | 105.2 kb | Distal (>10kb) Multiome | 643 |
Genomic view of the ADIPOR2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.