This gene encodes a protein that forms part of the Sec16 complex. This protein has a role in protein transport from the endoplasmic reticulum (ER) to the Golgi and mediates COPII vesicle formation at the transitional ER. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Feb 2013]
Transcription factors with Perturb-seq knockdown data for SEC16A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SEC16A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SEC16A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:136,245,219–136,246,310 | 237.2 kb | Distal (>10kb) Multiome | 608 | |
| chr9:136,267,002–136,267,928 | 215.6 kb | Distal (>10kb) Multiome | 459 | |
| chr9:136,327,140–136,327,919 | 155.4 kb | Distal (>10kb) Multiome | 310 | |
| chr9:136,342,464–136,343,245 | 140.1 kb | Distal (>10kb) Multiome | 326 | |
| chr9:136,362,899–136,364,677 | 119.7 kb | Distal (>10kb) Multiome | 969 | |
| chr9:136,399,639–136,400,642 | 82.8 kb | Distal (>10kb) Multiome | 776 | |
| chr9:136,410,307–136,410,943 | 72.4 kb | Distal (>10kb) Multiome | 740 | |
| chr9:136,438,826–136,440,227 | 43.2 kb | Distal (>10kb) Multiome | 608 | |
| chr9:136,482,405–136,485,297 | 310 bp | At TSS Multiome | 938 | |
| chr9:136,488,724–136,488,907 | 5.7 kb | Proximal (<10kb) | 283 | |
| chr9:136,545,392–136,547,129 | 63.1 kb | Distal (>10kb) Multiome HiCAR | 710 | |
| chr9:136,572,053–136,572,865 | 89.3 kb | Distal (>10kb) Multiome | 239 | |
| chr9:136,587,135–136,588,835 | 105.3 kb | Distal (>10kb) Multiome | 453 | |
| chr9:136,626,479–136,627,366 | 143.9 kb | Distal (>10kb) Multiome HiCAR | 451 | |
| chr9:136,665,223–136,666,507 | 182.8 kb | Distal (>10kb) Multiome | 409 | |
| chr9:136,686,875–136,688,079 | 204.4 kb | Distal (>10kb) Multiome | 610 | |
| chr9:136,711,795–136,713,743 | 229.4 kb | Distal (>10kb) Multiome | 459 | |
| chr9:136,727,616–136,729,079 | 245.2 kb | Distal (>10kb) Multiome | 1013 | |
| chr9:136,762,846–136,763,902 | 280.2 kb | Distal (>10kb) Multiome | 271 |
Genomic view of the SEC16A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.