This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jan 2014]
Transcription factors with Perturb-seq knockdown data for MAPK1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAPK1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAPK1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:21,567,510–21,568,436 | 299.9 kb | Distal (>10kb) Multiome | 951 | |
| chr22:21,628,821–21,630,259 | 237.6 kb | Distal (>10kb) Multiome | 1055 | |
| chr22:21,641,511–21,643,313 | 225.5 kb | Distal (>10kb) Multiome | 754 | |
| chr22:21,651,622–21,652,445 | 215.5 kb | Distal (>10kb) Multiome | 719 | |
| chr22:21,657,073–21,658,429 | 210.0 kb | Distal (>10kb) Multiome | 802 | |
| chr22:21,665,721–21,666,577 | 201.5 kb | Distal (>10kb) Multiome | 893 | |
| chr22:21,735,345–21,736,601 | 131.7 kb | Distal (>10kb) Multiome | 774 | |
| chr22:21,864,937–21,865,391 | 2.6 kb | Proximal (<10kb) Multiome | 184 | |
| chr22:21,866,936–21,868,402 | 172 bp | At TSS Multiome | 929 | |
| chr22:21,925,450–21,926,079 | 58.2 kb | Distal (>10kb) Multiome | 169 | |
| chr22:21,938,040–21,938,786 | 70.7 kb | Distal (>10kb) Multiome | 871 | |
| chr22:21,951,964–21,953,251 | 85.2 kb | Distal (>10kb) Multiome | 645 |
Genomic view of the MAPK1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.