This gene encodes a member of the ARID (AT-rich interaction domain) family of DNA-binding proteins. The encoded protein is homologous with two proteins that bind to the retinoblastoma gene product, and also with the mouse Bright and Drosophila dead ringer proteins. A pseudogene on chromosome 1p31 exists for this gene. Members of the ARID family have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation and possibly in chromatin structure modification. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ARID3B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARID3B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARID3B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:74,245,168–74,245,975 | 295.7 kb | Distal (>10kb) Multiome | 278 | |
| chr15:74,291,174–74,291,950 | 249.8 kb | Distal (>10kb) Multiome | 773 | |
| chr15:74,354,072–74,354,610 | 186.9 kb | Distal (>10kb) Multiome | 15 | |
| chr15:74,365,599–74,366,233 | 175.3 kb | Distal (>10kb) Multiome | 441 | |
| chr15:74,373,469–74,375,034 | 166.8 kb | Distal (>10kb) Multiome HiCAR | 745 | |
| chr15:74,433,053–74,434,500 | 107.3 kb | Distal (>10kb) Multiome | 695 | |
| chr15:74,460,798–74,461,761 | 80.0 kb | Distal (>10kb) Multiome | 925 | |
| chr15:74,531,382–74,531,884 | 9.6 kb | Proximal (<10kb) Multiome | 217 | |
| chr15:74,540,389–74,542,119 | 129 bp | At TSS Multiome | 838 | |
| chr15:74,550,169–74,550,493 | 8.9 kb | Proximal (<10kb) | 17 | |
| chr15:74,598,102–74,598,966 | 57.2 kb | Distal (>10kb) Multiome | 689 | |
| chr15:74,614,343–74,616,348 | 74.5 kb | Distal (>10kb) Multiome | 1019 | |
| chr15:74,695,758–74,696,387 | 154.8 kb | Distal (>10kb) Multiome | 775 | |
| chr15:74,720,336–74,720,840 | 179.4 kb | Distal (>10kb) Multiome | 16 | |
| chr15:74,725,773–74,726,537 | 184.9 kb | Distal (>10kb) Multiome | 607 | |
| chr15:74,759,107–74,760,837 | 219.1 kb | Distal (>10kb) Multiome | 637 | |
| chr15:74,761,837–74,762,260 | 220.9 kb | Distal (>10kb) Multiome | 34 | |
| chr15:74,770,975–74,771,578 | 230.0 kb | Distal (>10kb) Multiome | 485 | |
| chr15:74,781,439–74,783,648 | 240.8 kb | Distal (>10kb) Multiome | 679 |
Genomic view of the ARID3B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.