CSNK1A1
casein kinase 1 alpha 1 | CK1, CK1a, CK1alpha, CKIa, CKIalpha

Enables protein serine/threonine kinase activity. Involved in several processes, including intermediate filament cytoskeleton organization; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; and regulation of signal transduction. Located in cytoskeleton and nucleus. Part of beta-catenin destruction complex. Biomarker of Alzheimer's disease and inclusion body myositis. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-2 DE-2.2
Biological processes 51 terms
ATP binding (GO:0005524)Golgi organization (GO:0007030)Wnt signaling pathway (GO:0016055)beta-catenin destruction complex (GO:0030877)cell surface receptor signaling pathway (GO:0007166)cellular response to nutrient (GO:0031670)centrosome (GO:0005813)centrosome (GO:0005813)ciliary basal body (GO:0036064)cilium (GO:0005929)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)intermediate filament cytoskeleton organization (GO:0045104)keratin filament (GO:0045095)mRNA cleavage and polyadenylation specificity factor complex (GO:0005847)membrane (GO:0016020)negative regulation of NLRP3 inflammasome complex assembly (GO:1900226)negative regulation of canonical Wnt signaling pathway (GO:0090090)negative regulation of canonical Wnt signaling pathway (GO:0090090)negative regulation of canonical Wnt signaling pathway (GO:0090090)nuclear speck (GO:0016607)nuclear speck (GO:0016607)nucleoplasm (GO:0005654)nucleus (GO:0005634)positive regulation of Rho protein signal transduction (GO:0035025)positive regulation of TORC1 signaling (GO:1904263)positive regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032436)positive regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032436)proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)protein binding (GO:0005515)protein kinase activity (GO:0004672)protein kinase activity (GO:0004672)protein kinase activity (GO:0004672)protein phosphorylation (GO:0006468)protein phosphorylation (GO:0006468)protein serine kinase activity (GO:0106310)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)regulation of Wnt signaling pathway (GO:0030111)signal transduction (GO:0007165)signal transduction (GO:0007165)spindle (GO:0005819)spindle (GO:0005819)viral protein processing (GO:0019082)
Expression (TPM)
CSNK1A1 — as a Regulated Gene

TFs regulating CSNK1A1 0 TFs

Transcription factors with Perturb-seq knockdown data for CSNK1A1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CSNK1A1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to CSNK1A1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CSNK1A1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr5:149,264,564–149,265,053 286.6 kb Distal (>10kb) Multiome 184
chr5:149,271,306–149,272,588 279.6 kb Distal (>10kb) Multiome 470
chr5:149,273,332–149,274,284 277.6 kb Distal (>10kb) Multiome 77
chr5:149,344,876–149,346,055 206.0 kb Distal (>10kb) Multiome 998
chr5:149,357,500–149,358,624 193.5 kb Distal (>10kb) Multiome 674
chr5:149,367,315–149,368,054 183.8 kb Distal (>10kb) Multiome 450
chr5:149,371,224–149,371,844 179.9 kb Distal (>10kb) Multiome 189
chr5:149,381,769–149,382,370 169.4 kb Distal (>10kb) Multiome HiCAR 395
chr5:149,402,230–149,402,797 149.0 kb Distal (>10kb) Multiome 18
chr5:149,550,938–149,552,144 116 bp At TSS Multiome 1038
chr5:149,581,015–149,581,833 29.9 kb Distal (>10kb) Multiome 422
chr5:149,729,917–149,732,346 178.8 kb Distal (>10kb) Multiome 829

Genome Browser

Genomic view of the CSNK1A1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr5:149,254,564 – 149,742,346
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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