This locus encodes a guanine nucleotide-binding protein. The encoded protein, an alpha subunit in the Gq class, couples a seven-transmembrane domain receptor to activation of phospolipase C-beta. Mutations at this locus have been associated with problems in platelet activation and aggregation. A related pseudogene exists on chromosome 2.[provided by RefSeq, Nov 2010]
Transcription factors with Perturb-seq knockdown data for GNAQ. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GNAQ upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GNAQ, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:77,916,555–77,917,423 | 114.9 kb | Distal (>10kb) Multiome | 99 | |
| chr9:78,021,838–78,022,242 | 9.6 kb | Proximal (<10kb) | 121 | |
| chr9:78,030,155–78,032,794 | 240 bp | At TSS Multiome | 734 | |
| chr9:78,035,370–78,035,706 | 3.6 kb | Proximal (<10kb) | 182 | |
| chr9:78,235,450–78,236,885 | 204.3 kb | Distal (>10kb) Multiome | 857 | |
| chr9:78,296,116–78,298,522 | 265.3 kb | Distal (>10kb) Multiome | 973 |
Genomic view of the GNAQ locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.