Vasoactive intestinal peptide is a neuroprotective factor that has a stimulatory effect on the growth of some tumor cells and an inhibitory effect on others. This gene encodes a protein that is upregulated by vasoactive intestinal peptide and may be involved in its stimulatory effect on certain tumor cells. The encoded protein contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor. This gene is also upregulated in normal proliferative tissues. Finally, the encoded protein may increase the viability of certain cell types through modulation of p53 activity. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ADNP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ADNP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ADNP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:50,635,765–50,636,791 | 295.4 kb | Distal (>10kb) Multiome | 720 | |
| chr20:50,641,661–50,642,825 | 289.0 kb | Distal (>10kb) Multiome | 190 | |
| chr20:50,645,216–50,645,868 | 285.8 kb | Distal (>10kb) Multiome | 792 | |
| chr20:50,730,245–50,732,382 | 200.2 kb | Distal (>10kb) Multiome | 1014 | |
| chr20:50,767,314–50,767,756 | 163.9 kb | Distal (>10kb) Multiome | 140 | |
| chr20:50,790,529–50,791,153 | 140.6 kb | Distal (>10kb) Multiome | 980 | |
| chr20:50,794,408–50,795,648 | 136.5 kb | Distal (>10kb) Multiome | 794 | |
| chr20:50,818,246–50,818,886 | 112.9 kb | Distal (>10kb) Multiome | 844 | |
| chr20:50,870,405–50,871,527 | 60.5 kb | Distal (>10kb) Multiome | 254 | |
| chr20:50,929,398–50,929,709 | 1.7 kb | Proximal (<10kb) | 857 | |
| chr20:50,929,968–50,930,097 | 1.3 kb | Proximal (<10kb) | 285 | |
| chr20:50,930,214–50,932,320 | 213 bp | At TSS Multiome | 1082 | |
| chr20:50,958,262–50,959,227 | 27.2 kb | Distal (>10kb) Multiome | 929 | |
| chr20:50,992,251–50,993,606 | 61.7 kb | Distal (>10kb) Multiome | 409 | |
| chr20:51,022,526–51,023,913 | 91.8 kb | Distal (>10kb) Multiome | 437 | |
| chr20:51,091,663–51,092,800 | 160.6 kb | Distal (>10kb) Multiome | 122 | |
| chr20:51,221,628–51,222,684 | 290.6 kb | Distal (>10kb) Multiome | 366 |
Genomic view of the ADNP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.