The protein encoded by this gene is part of a protease found in mitochondria. This protease is ATP-dependent and targets specific proteins for degradation. The protease consists of two heptameric rings of the CLPP catalytic subunit sandwiched between two hexameric rings of the chaperone subunit encoded by this gene. Targeted proteins are unwound by this protein and then passed on to the CLPP subunit for degradation. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Nov 2015]
Transcription factors with Perturb-seq knockdown data for CLPX. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CLPX upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CLPX, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:64,893,790–64,894,635 | 291.2 kb | Distal (>10kb) Multiome | 506 | |
| chr15:64,905,276–64,905,958 | 279.7 kb | Distal (>10kb) Multiome | 362 | |
| chr15:64,911,481–64,912,188 | 273.6 kb | Distal (>10kb) Multiome | 308 | |
| chr15:64,915,576–64,916,281 | 269.4 kb | Distal (>10kb) Multiome | 115 | |
| chr15:64,989,345–64,990,371 | 195.4 kb | Distal (>10kb) Multiome | 859 | |
| chr15:65,028,915–65,029,974 | 155.8 kb | Distal (>10kb) Multiome | 703 | |
| chr15:65,049,359–65,049,794 | 135.8 kb | Distal (>10kb) Multiome | 267 | |
| chr15:65,067,081–65,068,384 | 117.2 kb | Distal (>10kb) Multiome | 131 | |
| chr15:65,101,638–65,102,425 | 83.4 kb | Distal (>10kb) Multiome | 204 | |
| chr15:65,132,889–65,133,960 | 51.6 kb | Distal (>10kb) Multiome | 775 | |
| chr15:65,184,434–65,185,938 | 119 bp | At TSS Multiome | 985 | |
| chr15:65,286,029–65,287,330 | 101.6 kb | Distal (>10kb) Multiome HiCAR | 919 | |
| chr15:65,295,595–65,297,682 | 110.9 kb | Distal (>10kb) Multiome HiCAR | 1039 | |
| chr15:65,299,879–65,301,676 | 115.7 kb | Distal (>10kb) Multiome HiCAR | 464 | |
| chr15:65,303,709–65,305,825 | 119.5 kb | Distal (>10kb) Multiome HiCAR | 1230 | |
| chr15:65,355,116–65,356,095 | 170.3 kb | Distal (>10kb) Multiome | 288 | |
| chr15:65,376,859–65,378,657 | 192.7 kb | Distal (>10kb) Multiome | 612 | |
| chr15:65,384,869–65,386,083 | 200.4 kb | Distal (>10kb) Multiome | 703 | |
| chr15:65,400,812–65,401,824 | 216.1 kb | Distal (>10kb) Multiome | 406 | |
| chr15:65,414,873–65,415,582 | 230.0 kb | Distal (>10kb) Multiome | 333 | |
| chr15:65,421,061–65,422,050 | 236.2 kb | Distal (>10kb) Multiome | 457 | |
| chr15:65,422,462–65,423,579 | 237.7 kb | Distal (>10kb) Multiome | 450 |
Genomic view of the CLPX locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.