This gene encodes the beta subunit of the karyopherin receptor complex which interacts with nuclear localization signals to target nuclear proteins to the nucleus. The karyopherin receptor complex is a heterodimer of an alpha subunit which recognizes the nuclear localization signal and a beta subunit which docks the complex at nucleoporins. Alternate splicing of this gene results in several transcript variants encoding different proteins. [provided by RefSeq, Jun 2018]
Transcription factors with Perturb-seq knockdown data for TNPO1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TNPO1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TNPO1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:72,541,250–72,542,235 | 274.8 kb | Distal (>10kb) Multiome HiCAR | 116 | |
| chr5:72,556,396–72,557,392 | 259.7 kb | Distal (>10kb) Multiome HiCAR | 362 | |
| chr5:72,816,070–72,817,456 | 16 bp | At TSS Multiome | 858 | |
| chr5:72,818,850–72,819,256 | 2.2 kb | Proximal (<10kb) | 212 | |
| chr5:72,847,979–72,849,263 | 31.6 kb | Distal (>10kb) Multiome | 947 | |
| chr5:72,955,335–72,956,832 | 139.3 kb | Distal (>10kb) Multiome | 941 | |
| chr5:73,119,738–73,120,989 | 303.9 kb | Distal (>10kb) Multiome | 332 |
Genomic view of the TNPO1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.