The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PLCG1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PLCG1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PLCG1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:40,949,667–40,950,138 | 187.7 kb | Distal (>10kb) Multiome | 26 | |
| chr20:40,990,562–40,991,029 | 146.8 kb | Distal (>10kb) Multiome | 486 | |
| chr20:41,028,014–41,029,610 | 108.9 kb | Distal (>10kb) Multiome | 977 | |
| chr20:41,135,300–41,135,808 | 2.1 kb | Proximal (<10kb) Multiome | 451 | |
| chr20:41,136,345–41,138,443 | 296 bp | At TSS Multiome | 1007 | |
| chr20:41,249,859–41,250,320 | 112.5 kb | Distal (>10kb) Multiome | 183 | |
| chr20:41,316,979–41,318,388 | 180.2 kb | Distal (>10kb) Multiome | 894 | |
| chr20:41,339,588–41,341,431 | 203.2 kb | Distal (>10kb) Multiome | 904 | |
| chr20:41,365,890–41,367,375 | 229.3 kb | Distal (>10kb) Multiome | 273 |
Genomic view of the PLCG1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.