ZNF655

zinc finger protein 655 | VIK, VIK-1

This gene encodes a zinc finger protein. The zinc finger proteins are involved in DNA binding and protein-protein interactions. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Member of: DE-2 DE-2.10

Biological processes 12 terms

DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)cytoplasm (GO:0005737)negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)nucleolus (GO:0005730)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)plasma membrane (GO:0005886)protein binding (GO:0005515)regulation of transcription by RNA polymerase II (GO:0006357)

Expression (TPM)

TFs regulating ZNF655 0 TFs

Transcription factors with Perturb-seq knockdown data for ZNF655. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF655 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ZNF655

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF655, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr7:99,325,304–99,326,401	232.8 kb	Distal (>10kb) Multiome	858
chr7:99,373,955–99,375,619	183.1 kb	Distal (>10kb) Multiome	759
chr7:99,392,361–99,394,025	165.5 kb	Distal (>10kb) Multiome	486
chr7:99,407,975–99,409,432	149.9 kb	Distal (>10kb) Multiome	975
chr7:99,438,371–99,439,668	119.6 kb	Distal (>10kb) Multiome	881
chr7:99,465,842–99,466,381	92.5 kb	Distal (>10kb) Multiome	949
chr7:99,471,690–99,473,325	85.9 kb	Distal (>10kb) Multiome	861
chr7:99,499,759–99,500,629	58.4 kb	Distal (>10kb) Multiome	809
chr7:99,504,224–99,505,507	53.9 kb	Distal (>10kb) Multiome	881
chr7:99,551,826–99,552,261	6.4 kb	Proximal (<10kb)	766
chr7:99,557,927–99,559,319	22 bp	At TSS Multiome	922
chr7:99,580,108–99,580,792	21.7 kb	Distal (>10kb) Multiome	296
chr7:99,616,474–99,617,353	58.2 kb	Distal (>10kb) Multiome	1043
chr7:99,693,257–99,693,867	134.9 kb	Distal (>10kb) Multiome	518
chr7:99,839,578–99,840,069	281.2 kb	Distal (>10kb) Multiome	85

Genome Browser

Genomic view of the ZNF655 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.