This gene encodes a cilia-associated protein belonging to the kinesin family. This protein plays a role in the sonic hedgehog (SHH) signaling pathway through the regulation of GLI transcription factors. It functions as a negative regulator of the SHH pathway by preventing inappropriate activation of GLI2 in the absence of ligand, and as a positive regulator by preventing the processing of GLI3 into its repressor form. Mutations in this gene have been associated with various ciliopathies. [provided by RefSeq, Oct 2011]
Transcription factors with Perturb-seq knockdown data for KIF7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KIF7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KIF7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:89,358,633–89,359,313 | 296.6 kb | Distal (>10kb) Multiome | 569 | |
| chr15:89,367,305–89,368,054 | 287.8 kb | Distal (>10kb) Multiome | 267 | |
| chr15:89,371,087–89,371,852 | 283.9 kb | Distal (>10kb) Multiome | 122 | |
| chr15:89,399,210–89,400,654 | 255.6 kb | Distal (>10kb) Multiome | 464 | |
| chr15:89,407,314–89,408,300 | 247.5 kb | Distal (>10kb) Multiome | 207 | |
| chr15:89,411,338–89,411,946 | 243.8 kb | Distal (>10kb) Multiome | 362 | |
| chr15:89,416,314–89,416,831 | 238.9 kb | Distal (>10kb) Multiome | 411 | |
| chr15:89,430,551–89,431,192 | 224.6 kb | Distal (>10kb) Multiome | 520 | |
| chr15:89,496,217–89,496,744 | 159.0 kb | Distal (>10kb) Multiome | 337 | |
| chr15:89,575,079–89,576,170 | 80.1 kb | Distal (>10kb) Multiome | 805 | |
| chr15:89,647,189–89,647,621 | 8.1 kb | Proximal (<10kb) Multiome | 323 | |
| chr15:89,654,859–89,655,986 | 12 bp | At TSS Multiome | 484 | |
| chr15:89,665,508–89,666,065 | 10.3 kb | Distal (>10kb) Multiome | 279 | |
| chr15:89,690,263–89,691,125 | 35.3 kb | Distal (>10kb) Multiome | 669 | |
| chr15:89,747,326–89,748,774 | 92.6 kb | Distal (>10kb) Multiome | 214 | |
| chr15:89,750,169–89,751,978 | 95.5 kb | Distal (>10kb) Multiome | 732 | |
| chr15:89,760,201–89,761,182 | 105.3 kb | Distal (>10kb) Multiome | 473 | |
| chr15:89,775,879–89,777,425 | 121.2 kb | Distal (>10kb) Multiome | 647 | |
| chr15:89,893,669–89,894,442 | 238.6 kb | Distal (>10kb) Multiome | 1083 | |
| chr15:89,912,261–89,913,121 | 257.4 kb | Distal (>10kb) Multiome | 514 |
Genomic view of the KIF7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.