MAVS

MAVS

mitochondrial antiviral signaling protein | Cardif, IPS-1, KIAA1271, VISA

This gene encodes an intermediary protein necessary in the virus-triggered beta interferon signaling pathways. It is required for activation of transcription factors which regulate expression of beta interferon and contributes to antiviral innate immunity. [provided by RefSeq, Jul 2020]

Member of: DE-2 DE-2.31 Developmental clusters: GC6

Biological processes 72 terms

CARD domain binding (GO:0050700)DNA-binding transcription factor binding (GO:0140297)activation of innate immune response (GO:0002218)antiviral innate immune response (GO:0140374)antiviral innate immune response (GO:0140374)cellular response to exogenous dsRNA (GO:0071360)cellular response to interferon-beta (GO:0035458)cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)defense response to bacterium (GO:0042742)defense response to virus (GO:0051607)defense response to virus (GO:0051607)identical protein binding (GO:0042802)innate immune response (GO:0045087)intracellular signal transduction (GO:0035556)mitochondrial membrane (GO:0031966)mitochondrial membrane (GO:0031966)mitochondrial outer membrane (GO:0005741)mitochondrial outer membrane (GO:0005741)mitochondrial outer membrane (GO:0005741)mitochondrial outer membrane (GO:0005741)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion (GO:0005739)molecular adaptor activity (GO:0060090)molecular condensate scaffold activity (GO:0140693)negative regulation of viral genome replication (GO:0045071)negative regulation of viral genome replication (GO:0045071)peroxisomal membrane (GO:0005778)peroxisome (GO:0005777)positive regulation of IP-10 production (GO:0071660)positive regulation of NLRP3 inflammasome complex assembly (GO:1900227)positive regulation of NLRP3 inflammasome complex assembly (GO:1900227)positive regulation of canonical NF-kappaB signal transduction (GO:0043123)positive regulation of canonical NF-kappaB signal transduction (GO:0043123)positive regulation of chemokine (C-C motif) ligand 5 production (GO:0071651)positive regulation of defense response to virus by host (GO:0002230)positive regulation of defense response to virus by host (GO:0002230)positive regulation of defense response to virus by host (GO:0002230)positive regulation of interferon-alpha production (GO:0032727)positive regulation of interferon-alpha production (GO:0032727)positive regulation of interferon-alpha production (GO:0032727)positive regulation of interferon-beta production (GO:0032728)positive regulation of interferon-beta production (GO:0032728)positive regulation of interferon-beta production (GO:0032728)positive regulation of interferon-beta production (GO:0032728)positive regulation of interleukin-6 production (GO:0032755)positive regulation of interleukin-6 production (GO:0032755)positive regulation of interleukin-8 production (GO:0032757)positive regulation of myeloid dendritic cell cytokine production (GO:0002735)positive regulation of protein import into nucleus (GO:0042307)positive regulation of response to cytokine stimulus (GO:0060760)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of tumor necrosis factor production (GO:0032760)positive regulation of tumor necrosis factor production (GO:0032760)positive regulation of type I interferon production (GO:0032481)positive regulation of type I interferon-mediated signaling pathway (GO:0060340)protein binding (GO:0005515)protein kinase binding (GO:0019901)protein localization to mitochondrion (GO:0070585)protein localization to mitochondrion (GO:0070585)protein serine/threonine kinase binding (GO:0120283)protein tetramerization (GO:0051262)protein-macromolecule adaptor activity (GO:0030674)regulation of peroxisome organization (GO:1900063)regulation of peroxisome organization (GO:1900063)signal transduction (GO:0007165)signaling adaptor activity (GO:0035591)signaling adaptor activity (GO:0035591)signaling adaptor activity (GO:0035591)type I interferon-mediated signaling pathway (GO:0060337)

Expression (TPM)

TFs regulating MAVS 0 TFs

Transcription factors with Perturb-seq knockdown data for MAVS. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAVS upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to MAVS

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAVS, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility	Element	Dist. to TSS	Link type	TFs
	chr20:3,672,530–3,673,055	174.2 kb	Distal (>10kb) Multiome	158
	chr20:3,681,778–3,682,557	164.7 kb	Distal (>10kb) Multiome	170
	chr20:3,732,150–3,733,030	114.2 kb	Distal (>10kb) Multiome	192
	chr20:3,744,813–3,745,795	101.6 kb	Distal (>10kb) Multiome	379
	chr20:3,749,619–3,750,251	96.9 kb	Distal (>10kb) Multiome	520
	chr20:3,751,352–3,752,738	94.7 kb	Distal (>10kb) Multiome	261
	chr20:3,767,155–3,768,879	78.9 kb	Distal (>10kb) Multiome	1011
	chr20:3,777,516–3,778,624	68.7 kb	Distal (>10kb) Multiome	428
	chr20:3,781,161–3,781,797	65.4 kb	Distal (>10kb) Multiome	595
	chr20:3,785,713–3,787,025	60.0 kb	Distal (>10kb) Multiome	695
	chr20:3,795,543–3,796,972	50.7 kb	Distal (>10kb) Multiome	925
	chr20:3,799,527–3,800,087	47.1 kb	Distal (>10kb) Multiome	197
	chr20:3,820,073–3,821,115	26.3 kb	Distal (>10kb) Multiome	1081
	chr20:3,846,214–3,847,496	12 bp	At TSS Multiome	940
	chr20:3,855,176–3,855,341	8.3 kb	Proximal (<10kb)	250
	chr20:3,875,544–3,876,019	29.1 kb	Distal (>10kb) Multiome	80
	chr20:3,888,329–3,890,033	42.3 kb	Distal (>10kb) Multiome	1031
	chr20:4,014,730–4,016,019	168.8 kb	Distal (>10kb) Multiome	865
	chr20:4,064,484–4,064,955	217.8 kb	Distal (>10kb) Multiome	290
	chr20:4,082,773–4,083,490	236.3 kb	Distal (>10kb) Multiome	445
	chr20:4,085,118–4,085,823	238.6 kb	Distal (>10kb) Multiome	674
	chr20:4,108,490–4,109,121	262.0 kb	Distal (>10kb) Multiome	600

Genome Browser

Genomic view of the MAVS locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.