FOXK1

forkhead box K1 | IMAGE:5164497

Enables 14-3-3 protein binding activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; and transcription cis-regulatory region binding activity. Involved in several processes, including intracellular glucose homeostasis; negative regulation of autophagy; and regulation of DNA-templated transcription. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-2 DE-2.36 Developmental clusters: GC6

Biological processes 35 terms

14-3-3 protein binding (GO:0071889)DNA binding (GO:0003677)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977)canonical glycolysis (GO:0061621)chromatin (GO:0000785)cytoplasm (GO:0005737)cytoplasm (GO:0005737)intracellular glucose homeostasis (GO:0001678)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of autophagy (GO:0010507)negative regulation of transcription by RNA polymerase II (GO:0000122)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of DNA-templated transcription (GO:0045893)protein binding (GO:0005515)regulation of DNA-templated transcription (GO:0006355)regulation of glucose metabolic process (GO:0010906)regulation of transcription by RNA polymerase II (GO:0006357)response to starvation (GO:0042594)sequence-specific DNA binding (GO:0043565)sequence-specific double-stranded DNA binding (GO:1990837)transcription cis-regulatory region binding (GO:0000976)transcription cis-regulatory region binding (GO:0000976)

Expression (TPM)

TFs regulating FOXK1 0 TFs

Transcription factors with Perturb-seq knockdown data for FOXK1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FOXK1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to FOXK1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FOXK1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr7:4,625,503–4,626,335	56.3 kb	Distal (>10kb) Multiome	189
chr7:4,631,373–4,632,184	50.5 kb	Distal (>10kb) Multiome	464
chr7:4,641,264–4,642,525	40.4 kb	Distal (>10kb) Multiome	1072
chr7:4,681,869–4,682,504	64 bp	At TSS Multiome	517
chr7:4,700,808–4,701,595	18.9 kb	Distal (>10kb) Multiome	166
chr7:4,707,922–4,708,359	25.9 kb	Distal (>10kb) Multiome	107
chr7:4,744,414–4,745,493	62.9 kb	Distal (>10kb) Multiome	673
chr7:4,775,021–4,775,903	93.3 kb	Distal (>10kb) Multiome	860
chr7:4,791,775–4,793,216	110.1 kb	Distal (>10kb) Multiome	359
chr7:4,798,157–4,798,757	116.0 kb	Distal (>10kb) Multiome	349
chr7:4,845,690–4,846,237	163.7 kb	Distal (>10kb) Multiome	165
chr7:4,882,152–4,884,513	201.4 kb	Distal (>10kb) Multiome	585
chr7:4,973,785–4,974,732	291.8 kb	Distal (>10kb) Multiome	674

Genome Browser

Genomic view of the FOXK1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.