SMO

SMO

smoothened, frizzled class receptor | FZD11, SMOH

The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex. [provided by RefSeq, Jul 2010]

Member of: DE-2 DE-2.5

Biological processes 84 terms

9+0 non-motile cilium (GO:0097731)G protein-coupled receptor activity (GO:0004930)G protein-coupled receptor activity (GO:0004930)Golgi apparatus (GO:0005794)Golgi apparatus (GO:0005794)adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (GO:0007193)adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (GO:0007193)caveola (GO:0005901)cell surface receptor signaling pathway (GO:0007166)cellular response to cholesterol (GO:0071397)cellular response to cholesterol (GO:0071397)central nervous system development (GO:0007417)centriole (GO:0005814)cholesterol binding (GO:0015485)cholesterol binding (GO:0015485)ciliary membrane (GO:0060170)ciliary membrane (GO:0060170)ciliary tip (GO:0097542)cilium (GO:0005929)cilium (GO:0005929)cilium (GO:0005929)cilium (GO:0005929)cilium (GO:0005929)commissural neuron axon guidance (GO:0071679)contact inhibition (GO:0060242)cytoplasm (GO:0005737)dendrite (GO:0030425)determination of left/right asymmetry in lateral mesoderm (GO:0003140)determination of left/right asymmetry in lateral mesoderm (GO:0003140)endocytic vesicle membrane (GO:0030666)endoplasmic reticulum (GO:0005783)endoplasmic reticulum-Golgi intermediate compartment (GO:0005793)extracellular exosome (GO:0070062)forebrain morphogenesis (GO:0048853)forebrain morphogenesis (GO:0048853)heart looping (GO:0001947)heart looping (GO:0001947)late endosome (GO:0005770)membrane (GO:0016020)mesenchymal to epithelial transition involved in metanephric renal vesicle formation (GO:0072285)mesenchymal to epithelial transition involved in metanephric renal vesicle formation (GO:0072285)midgut development (GO:0007494)midgut development (GO:0007494)negative regulation of DNA-templated transcription (GO:0045892)non-motile cilium membrane (GO:0098804)non-motile cilium membrane (GO:0098804)oxysterol binding (GO:0008142)oxysterol binding (GO:0008142)patched binding (GO:0005113)patched binding (GO:0005113)pattern specification process (GO:0007389)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane bounded cell projection (GO:0120025)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)positive regulation of cell migration (GO:0030335)positive regulation of gene expression (GO:0010628)positive regulation of multicellular organism growth (GO:0040018)positive regulation of organ growth (GO:0046622)positive regulation of smoothened signaling pathway (GO:0045880)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)protein kinase A catalytic subunit binding (GO:0034236)protein kinase A catalytic subunit binding (GO:0034236)protein sequestering activity (GO:0140311)protein sequestering activity (GO:0140311)regulation of heart morphogenesis (GO:2000826)regulation of heart morphogenesis (GO:2000826)smooth muscle tissue development (GO:0048745)smoothened signaling pathway (GO:0007224)smoothened signaling pathway (GO:0007224)smoothened signaling pathway (GO:0007224)smoothened signaling pathway (GO:0007224)smoothened signaling pathway (GO:0007224)somite development (GO:0061053)somite development (GO:0061053)spinal cord dorsal/ventral patterning (GO:0021513)tissue development (GO:0009888)transmembrane signaling receptor activity (GO:0004888)ventral midline determination (GO:0007371)ventral midline determination (GO:0007371)

Expression (TPM)

TFs regulating SMO 0 TFs

Transcription factors with Perturb-seq knockdown data for SMO. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SMO upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to SMO

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SMO, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility	Element	Dist. to TSS	Link type	TFs
	chr7:128,890,731–128,891,934	297.3 kb	Distal (>10kb) Multiome	231
	chr7:128,911,320–128,912,136	276.9 kb	Distal (>10kb) Multiome	216
	chr7:128,937,568–128,938,346	250.7 kb	Distal (>10kb) Multiome	392
	chr7:129,054,212–129,055,537	133.6 kb	Distal (>10kb) Multiome	1049
	chr7:129,144,393–129,145,068	43.9 kb	Distal (>10kb) Multiome	477
	chr7:129,168,405–129,170,130	19.4 kb	Distal (>10kb) Multiome	302
	chr7:129,188,088–129,189,694	27 bp	At TSS Multiome	603
	chr7:129,224,228–129,225,767	36.2 kb	Distal (>10kb) Multiome	899
	chr7:129,433,659–129,435,261	245.7 kb	Distal (>10kb) Multiome	770
	chr7:129,453,732–129,454,848	265.7 kb	Distal (>10kb) Multiome	197

Genome Browser

Genomic view of the SMO locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.