Enables 1-phosphatidylinositol binding activity; GTP-dependent protein binding activity; and protein homodimerization activity. Involved in endocytosis and vesicle fusion. Located in cytosol and early endosome membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for EEA1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EEA1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EEA1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:92,926,594–92,927,299 | 2.0 kb | Proximal (<10kb) | 146 | |
| chr12:92,928,462–92,929,929 | 88 bp | At TSS Multiome | 1056 | |
| chr12:93,019,922–93,021,053 | 91.4 kb | Distal (>10kb) Multiome | 563 | |
| chr12:93,022,700–93,023,746 | 93.9 kb | Distal (>10kb) Multiome | 237 | |
| chr12:93,080,230–93,081,786 | 151.3 kb | Distal (>10kb) Multiome | 272 | |
| chr12:93,087,158–93,088,100 | 158.2 kb | Distal (>10kb) Multiome | 624 | |
| chr12:93,106,981–93,107,741 | 178.0 kb | Distal (>10kb) Multiome | 95 | |
| chr12:93,467,156–93,468,248 | 538.3 kb | Distal (>10kb) Multiome HiCAR | 844 |
Genomic view of the EEA1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.