This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.[provided by RefSeq, Jun 2010]
Transcription factors with Perturb-seq knockdown data for NCOR1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NCOR1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NCOR1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:15,944,340–15,945,587 | 270.5 kb | Distal (>10kb) Multiome | 765 | |
| chr17:15,966,252–15,966,749 | 249.0 kb | Distal (>10kb) Multiome | 334 | |
| chr17:15,999,147–16,000,454 | 215.8 kb | Distal (>10kb) Multiome | 1029 | |
| chr17:16,214,816–16,216,252 | 40 bp | At TSS Multiome | 888 | |
| chr17:16,217,055–16,217,691 | 1.7 kb | Proximal (<10kb) Multiome | 911 | |
| chr17:16,352,703–16,353,919 | 138.0 kb | Distal (>10kb) Multiome | 714 | |
| chr17:16,380,399–16,381,729 | 165.3 kb | Distal (>10kb) Multiome | 1044 | |
| chr17:16,386,465–16,387,421 | 171.3 kb | Distal (>10kb) Multiome | 448 | |
| chr17:16,406,971–16,407,704 | 191.8 kb | Distal (>10kb) Multiome | 340 | |
| chr17:16,438,359–16,439,725 | 223.3 kb | Distal (>10kb) Multiome | 1006 | |
| chr17:16,442,894–16,444,373 | 228.3 kb | Distal (>10kb) Multiome | 388 | |
| chr17:16,491,363–16,492,722 | 276.7 kb | Distal (>10kb) Multiome | 312 |
Genomic view of the NCOR1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.