This gene encodes a protein containing four ankyrin repeats, a band 4.1/ezrin/radixin/moesin (FERM) domain, and multiple NPXY sequences. The encoded protein is localized in the nucleus and cytoplasm. It binds to integrin cytoplasmic domain-associated protein-1 alpha (ICAP1alpha), and plays a critical role in beta1-integrin-mediated cell proliferation. It associates with junction proteins and RAS-related protein 1A (Rap1A), which requires the encoded protein for maintaining the integrity of endothelial junctions. It is also a microtubule-associated protein and may play a role in microtubule targeting. Mutations in this gene result in cerebral cavernous malformations. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009]
Transcription factors with Perturb-seq knockdown data for KRIT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KRIT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KRIT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:92,133,257–92,135,349 | 112.1 kb | Distal (>10kb) Multiome | 1155 | |
| chr7:92,178,862–92,179,934 | 66.8 kb | Distal (>10kb) Multiome | 612 | |
| chr7:92,245,288–92,246,980 | 161 bp | At TSS Multiome | 964 | |
| chr7:92,424,381–92,424,856 | 178.7 kb | Distal (>10kb) Multiome | 634 | |
| chr7:92,447,026–92,448,601 | 201.6 kb | Distal (>10kb) Multiome | 973 | |
| chr7:92,483,511–92,484,016 | 237.8 kb | Distal (>10kb) Multiome | 84 | |
| chr7:92,527,585–92,529,221 | 282.7 kb | Distal (>10kb) Multiome | 921 |
Genomic view of the KRIT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.