This gene encodes a member of the AGC serine/threonine kinase family of proteins. The kinase activity of this protein is regulated by autophosphorylation and phosphorylation by other upstream kinases. This protein has been shown to function in the cell cycle and apoptosis. This protein has also been found to regulate the protein stability and transcriptional activity of the MYC oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Transcription factors with Perturb-seq knockdown data for STK38. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STK38 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STK38, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:36,284,908–36,285,433 | 262.2 kb | Distal (>10kb) Multiome | 104 | |
| chr6:36,360,373–36,360,968 | 186.8 kb | Distal (>10kb) Multiome | 348 | |
| chr6:36,368,910–36,369,452 | 178.3 kb | Distal (>10kb) Multiome | 68 | |
| chr6:36,387,482–36,388,139 | 159.6 kb | Distal (>10kb) Multiome | 262 | |
| chr6:36,423,143–36,423,810 | 124.1 kb | Distal (>10kb) Multiome | 886 | |
| chr6:36,442,626–36,443,451 | 104.5 kb | Distal (>10kb) Multiome | 982 | |
| chr6:36,546,941–36,548,024 | 12 bp | At TSS Multiome | 887 | |
| chr6:36,593,473–36,594,773 | 46.8 kb | Distal (>10kb) Multiome | 1156 | |
| chr6:36,650,865–36,651,585 | 103.7 kb | Distal (>10kb) Multiome | 207 | |
| chr6:36,678,325–36,679,788 | 131.2 kb | Distal (>10kb) Multiome | 955 |
Genomic view of the STK38 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.