Enables mRNA 3'-UTR binding activity and translation factor activity, RNA binding. Involved in cellular response to amino acid stimulus and regulation of gene expression. Located in several cellular components, including cytosol; midbody; and nucleoplasm. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CPEB3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CPEB3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CPEB3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:92,045,582–92,046,227 | 245.2 kb | Distal (>10kb) Multiome | 132 | |
| chr10:92,087,615–92,088,099 | 203.1 kb | Distal (>10kb) Multiome HiCAR | 401 | |
| chr10:92,290,248–92,291,760 | 30 bp | At TSS Multiome | 955 | |
| chr10:92,350,016–92,350,962 | 59.5 kb | Distal (>10kb) Multiome | 107 | |
| chr10:92,573,390–92,574,819 | 283.1 kb | Distal (>10kb) Multiome | 974 |
Genomic view of the CPEB3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.