Enables GTPase activity. Involved in selenocysteine incorporation. Predicted to be located in cytoplasm and nucleus. Predicted to be part of ribonucleoprotein complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for EEFSEC. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EEFSEC upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EEFSEC, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:128,051,597–128,052,755 | 101.4 kb | Distal (>10kb) Multiome | 839 | |
| chr3:128,075,184–128,076,787 | 78.0 kb | Distal (>10kb) Multiome | 509 | |
| chr3:128,123,342–128,124,277 | 29.8 kb | Distal (>10kb) Multiome | 873 | |
| chr3:128,153,057–128,154,021 | 217 bp | At TSS Multiome | 954 | |
| chr3:128,160,456–128,161,161 | 7.1 kb | Proximal (<10kb) Multiome | 21 | |
| chr3:128,161,271–128,161,567 | 7.8 kb | Proximal (<10kb) | 7 | |
| chr3:128,280,443–128,281,168 | 127.3 kb | Distal (>10kb) Multiome | 186 | |
| chr3:128,426,214–128,426,887 | 272.9 kb | Distal (>10kb) Multiome | 505 | |
| chr3:128,432,305–128,433,430 | 279.4 kb | Distal (>10kb) Multiome | 265 |
Genomic view of the EEFSEC locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.