ITPR3
inositol 1,4,5-trisphosphate receptor type 3 | IP3R3

This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. [provided by RefSeq, Aug 2010]

Member of: DE-2 DE-2.28 Developmental clusters: GC2
Biological processes 65 terms
ATP binding (GO:0005524)G protein-coupled receptor signaling pathway (GO:0007186)apical part of cell (GO:0045177)brush border (GO:0005903)calcium channel activity (GO:0005262)calcium ion binding (GO:0005509)calcium ion binding (GO:0005509)calcium ion homeostasis (GO:0055074)calcium ion transmembrane transport (GO:0070588)calcium ion transport (GO:0006816)calcium-mediated signaling (GO:0019722)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasmic side of endoplasmic reticulum membrane (GO:0098554)cytoplasmic side of endoplasmic reticulum membrane (GO:0098554)endoplasmic reticulum (GO:0005783)endoplasmic reticulum (GO:0005783)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum membrane (GO:0005789)inositol 1,3,4,5 tetrakisphosphate binding (GO:0043533)inositol 1,4,5 trisphosphate binding (GO:0070679)inositol 1,4,5 trisphosphate binding (GO:0070679)inositol 1,4,5 trisphosphate binding (GO:0070679)inositol 1,4,5-trisphosphate-gated calcium channel activity (GO:0005220)inositol 1,4,5-trisphosphate-gated calcium channel activity (GO:0005220)inositol 1,4,5-trisphosphate-gated calcium channel activity (GO:0005220)inositol 1,4,5-trisphosphate-gated calcium channel activity (GO:0005220)inositol hexakisphosphate binding (GO:0000822)intracellularly gated calcium channel activity (GO:0015278)intracellularly gated calcium channel activity (GO:0015278)intracellularly gated calcium channel activity (GO:0015278)intracellularly gated calcium channel activity (GO:0015278)membrane (GO:0016020)membrane (GO:0016020)monoatomic ion channel activity (GO:0005216)monoatomic ion transport (GO:0006811)neuronal cell body (GO:0043025)nuclear outer membrane (GO:0005640)nucleolus (GO:0005730)nucleoplasm (GO:0005654)nucleus (GO:0005634)phosphatidylinositol binding (GO:0035091)phosphatidylinositol binding (GO:0035091)plasma membrane (GO:0005886)plasma membrane (GO:0005886)platelet activation (GO:0030168)platelet dense tubular network membrane (GO:0031095)platelet dense tubular network membrane (GO:0031095)positive regulation of cytosolic calcium ion concentration (GO:0007204)protein binding (GO:0005515)protein homotetramerization (GO:0051289)release of sequestered calcium ion into cytosol (GO:0051209)release of sequestered calcium ion into cytosol (GO:0051209)response to calcium ion (GO:0051592)sarcoplasmic reticulum (GO:0016529)secretory granule membrane (GO:0030667)sensory perception of taste (GO:0050909)signaling receptor complex (GO:0043235)transmembrane transport (GO:0055085)transport vesicle membrane (GO:0030658)zinc ion binding (GO:0008270)
Expression (TPM)
ITPR3 — as a Regulated Gene

TFs regulating ITPR3 0 TFs

Transcription factors with Perturb-seq knockdown data for ITPR3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ITPR3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to ITPR3

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ITPR3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr6:33,322,636–33,323,832 298.2 kb Distal (>10kb) Multiome 941
chr6:33,346,609–33,347,126 274.5 kb Distal (>10kb) Multiome 37
chr6:33,390,888–33,392,247 229.7 kb Distal (>10kb) Multiome 993
chr6:33,409,936–33,411,502 210.8 kb Distal (>10kb) Multiome 977
chr6:33,417,606–33,419,249 203.1 kb Distal (>10kb) Multiome 973
chr6:33,419,793–33,420,532 201.1 kb Distal (>10kb) Multiome 162
chr6:33,425,590–33,426,362 195.4 kb Distal (>10kb) Multiome 665
chr6:33,431,024–33,432,096 190.1 kb Distal (>10kb) Multiome 337
chr6:33,454,074–33,454,852 166.8 kb Distal (>10kb) Multiome 906
chr6:33,547,185–33,548,324 73.6 kb Distal (>10kb) Multiome 155
chr6:33,570,899–33,571,638 49.9 kb Distal (>10kb) Multiome 755
chr6:33,579,935–33,580,700 41.0 kb Distal (>10kb) Multiome 639
chr6:33,592,764–33,593,449 28.4 kb Distal (>10kb) Multiome HiCAR 224
chr6:33,620,828–33,622,474 713 bp At TSS Multiome 594
chr6:33,632,607–33,634,721 11.3 kb Distal (>10kb) Multiome 600
chr6:33,711,017–33,712,173 90.4 kb Distal (>10kb) Multiome 943
chr6:33,771,283–33,772,101 150.4 kb Distal (>10kb) Multiome 478
chr6:33,788,007–33,789,360 167.9 kb Distal (>10kb) Multiome 999
chr6:33,828,845–33,829,529 207.6 kb Distal (>10kb) Multiome 97

Genome Browser

Genomic view of the ITPR3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr6:33,312,636 – 33,839,529
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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