This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CREM. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CREM upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CREM, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:35,089,654–35,090,939 | 36.5 kb | Distal (>10kb) Multiome | 797 | |
| chr10:35,126,359–35,127,943 | 44 bp | At TSS Multiome | 1045 | |
| chr10:35,335,922–35,337,633 | 209.6 kb | Distal (>10kb) Multiome | 701 | |
| chr10:35,384,192–35,385,102 | 257.6 kb | Distal (>10kb) Multiome | 160 | |
| chr10:35,414,119–35,414,985 | 287.6 kb | Distal (>10kb) Multiome | 293 |
Genomic view of the CREM locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.