This gene encodes a member of the Nedd4 family of E3 ligases, which play an important role in protein ubiquitination. The encoded protein contains four WW domains and may play a role in multiple processes including chondrogenesis and the regulation of oncogenic signaling pathways via interactions with Smad proteins and the tumor suppressor PTEN. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 10. [provided by RefSeq, Jul 2012]
Transcription factors with Perturb-seq knockdown data for WWP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WWP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WWP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:69,529,449–69,529,941 | 232.6 kb | Distal (>10kb) Multiome | 450 | |
| chr16:69,565,464–69,566,984 | 196.5 kb | Distal (>10kb) Multiome | 1044 | |
| chr16:69,726,315–69,727,097 | 35.7 kb | Distal (>10kb) Multiome | 879 | |
| chr16:69,754,401–69,755,306 | 7.3 kb | Proximal (<10kb) Multiome | 922 | |
| chr16:69,762,035–69,762,848 | 90 bp | At TSS Multiome | 847 |
Genomic view of the WWP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.