The protein encoded by this gene contains a pleckstrin homology (PH) domain and an oxysterol-binding region. It binds oxysterols such as 7-ketocholesterol and may inhibit their cytotoxicity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2013]
Transcription factors with Perturb-seq knockdown data for OSBP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = OSBP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of OSBP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:30,574,045–30,575,001 | 228.4 kb | Distal (>10kb) Multiome | 283 | |
| chr22:30,591,677–30,592,568 | 210.9 kb | Distal (>10kb) Multiome | 698 | |
| chr22:30,606,243–30,607,508 | 196.2 kb | Distal (>10kb) Multiome | 507 | |
| chr22:30,634,485–30,636,231 | 167.4 kb | Distal (>10kb) Multiome | 611 | |
| chr22:30,667,348–30,668,634 | 135.2 kb | Distal (>10kb) Multiome | 590 | |
| chr22:30,694,230–30,694,621 | 251 bp | At TSS | 364 | |
| chr22:30,694,739–30,695,381 | 108.3 kb | Distal (>10kb) Multiome | 278 | |
| chr22:30,802,592–30,803,363 | 156 bp | At TSS Multiome | 898 | |
| chr22:30,881,516–30,881,776 | at TSS | At TSS | 315 | |
| chr22:30,890,709–30,890,885 | 9.0 kb | Proximal (<10kb) | 129 | |
| chr22:30,968,406–30,969,906 | 166.0 kb | Distal (>10kb) Multiome | 897 | |
| chr22:31,080,687–31,081,783 | 278.1 kb | Distal (>10kb) Multiome | 636 | |
| chr22:31,084,596–31,085,743 | 282.0 kb | Distal (>10kb) Multiome | 448 | |
| chr22:31,098,574–31,099,237 | 295.8 kb | Distal (>10kb) Multiome | 150 |
Genomic view of the OSBP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.