This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family act as guanine nucleotide exchange factors for small Rho family G proteins. The protein encoded by this gene is thought to associate with adaptors CRK and CRKL, and function in regulation of intestinal epithelial cell spreading and migration on collagen IV. Similar proteins in mouse and zebrafish also function in myoblast fusion. [provided by RefSeq, Oct 2016]
Transcription factors with Perturb-seq knockdown data for DOCK5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DOCK5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DOCK5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:24,912,517–24,915,825 | 271.1 kb | Distal (>10kb) Multiome | 498 | |
| chr8:24,941,444–24,943,387 | 242.7 kb | Distal (>10kb) Multiome | 350 | |
| chr8:24,955,106–24,957,101 | 228.2 kb | Distal (>10kb) Multiome | 491 | |
| chr8:24,999,947–25,001,936 | 184.6 kb | Distal (>10kb) Multiome | 524 | |
| chr8:25,183,660–25,185,871 | 25 bp | At TSS Multiome | 631 | |
| chr8:25,457,415–25,459,756 | 273.9 kb | Distal (>10kb) Multiome | 971 | |
| chr8:26,064,268–26,065,352 | 880.1 kb | Distal (>10kb) Multiome HiCAR | 128 |
Genomic view of the DOCK5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.