This 84-gene module includes EP300, FBXW7, and CREBBP, with enrichment in mRNA catabolic processes, mRNA and RNA stability regulation, cytoplasmic stress granules, and histone modifying activity. Knockdown of SOX17, ZC3H3, and TCEB3 represses this module.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.