This gene encodes a member of the RAB family, which belongs to the small GTPase superfamily. GTPases of the RAB family bind to various effectors to regulate the targeting and fusion of transport carriers to acceptor compartments. This protein is located at the Golgi apparatus, which regulates trafficking in both a retrograde (from early endosomes and Golgi to the endoplasmic reticulum) and an anterograde (from the Golgi to the plasma membrane) directions. Myosin II is an effector of this protein in these processes. This protein is also involved in assembly of human cytomegalovirus (HCMV) by interacting with the cellular protein Bicaudal D1, which interacts with the HCMV virion tegument protein, pp150. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Transcription factors with Perturb-seq knockdown data for RAB6A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RAB6A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RAB6A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:73,597,688–73,598,911 | 162.8 kb | Distal (>10kb) Multiome | 887 | |
| chr11:73,645,683–73,646,788 | 114.9 kb | Distal (>10kb) Multiome | 193 | |
| chr11:73,647,445–73,647,968 | 113.5 kb | Distal (>10kb) Multiome | 442 | |
| chr11:73,660,644–73,661,627 | 99.9 kb | Distal (>10kb) Multiome | 525 | |
| chr11:73,760,242–73,761,712 | 111 bp | At TSS Multiome | 842 | |
| chr11:73,779,162–73,780,136 | 18.5 kb | Distal (>10kb) Multiome | 920 | |
| chr11:73,787,771–73,788,337 | 27.0 kb | Distal (>10kb) Multiome | 1000 | |
| chr11:73,876,432–73,877,378 | 115.8 kb | Distal (>10kb) Multiome | 911 | |
| chr11:73,982,330–73,983,905 | 222.0 kb | Distal (>10kb) Multiome | 1122 |
Genomic view of the RAB6A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.