Enables cargo receptor activity. Involved in several processes, including COPII-coated vesicle cargo loading; cell migration involved in sprouting angiogenesis; and regulation of leukocyte migration. Located in endoplasmic reticulum exit site and endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MIA3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MIA3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MIA3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:220,809,823–220,810,852 | 1818.1 kb | Distal (>10kb) Multiome HiCAR | 265 | |
| chr1:222,464,889–222,466,000 | 162.9 kb | Distal (>10kb) Multiome | 1097 | |
| chr1:222,589,519–222,590,254 | 38.6 kb | Distal (>10kb) Multiome | 689 | |
| chr1:222,617,261–222,619,333 | 10.6 kb | Distal (>10kb) Multiome | 690 | |
| chr1:222,634,501–222,634,703 | 6.0 kb | Proximal (<10kb) | 160 | |
| chr1:222,643,693–222,644,710 | 15.8 kb | Distal (>10kb) Multiome | 917 | |
| chr1:222,711,408–222,713,804 | 84.1 kb | Distal (>10kb) Multiome | 1037 | |
| chr1:222,814,519–222,815,531 | 186.6 kb | Distal (>10kb) Multiome | 704 |
Genomic view of the MIA3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.