The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Transcription factors with Perturb-seq knockdown data for MRTFA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MRTFA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MRTFA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:40,345,883–40,347,047 | 290.2 kb | Distal (>10kb) Multiome | 955 | |
| chr22:40,370,270–40,371,111 | 266.1 kb | Distal (>10kb) Multiome | 630 | |
| chr22:40,478,729–40,479,485 | 157.5 kb | Distal (>10kb) Multiome | 123 | |
| chr22:40,636,029–40,637,455 | 117 bp | At TSS Multiome | 903 | |
| chr22:40,646,313–40,646,511 | 9.6 kb | Proximal (<10kb) | 302 | |
| chr22:40,684,688–40,685,220 | 48.2 kb | Distal (>10kb) Multiome | 101 | |
| chr22:40,818,885–40,819,668 | 182.7 kb | Distal (>10kb) Multiome | 683 | |
| chr22:40,856,149–40,857,393 | 220.1 kb | Distal (>10kb) Multiome | 950 |
Genomic view of the MRTFA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.