The protein encoded by this gene shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this protein may interact with, and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in neuronal cells. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MAPK8IP3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAPK8IP3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAPK8IP3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:1,408,010–1,408,819 | 297.9 kb | Distal (>10kb) Multiome | 546 | |
| chr16:1,413,643–1,415,278 | 291.4 kb | Distal (>10kb) Multiome | 661 | |
| chr16:1,420,269–1,421,402 | 285.3 kb | Distal (>10kb) Multiome | 897 | |
| chr16:1,474,566–1,475,411 | 231.1 kb | Distal (>10kb) Multiome | 915 | |
| chr16:1,492,797–1,493,962 | 212.9 kb | Distal (>10kb) Multiome | 710 | |
| chr16:1,610,035–1,611,264 | 95.6 kb | Distal (>10kb) Multiome | 745 | |
| chr16:1,611,870–1,612,834 | 94.0 kb | Distal (>10kb) Multiome | 718 | |
| chr16:1,677,899–1,679,024 | 28.0 kb | Distal (>10kb) Multiome | 709 | |
| chr16:1,705,380–1,706,702 | 90 bp | At TSS Multiome | 933 | |
| chr16:1,763,511–1,764,353 | 57.8 kb | Distal (>10kb) Multiome | 261 | |
| chr16:1,770,847–1,771,973 | 65.4 kb | Distal (>10kb) Multiome | 485 | |
| chr16:1,772,565–1,774,049 | 67.2 kb | Distal (>10kb) Multiome | 956 | |
| chr16:1,781,749–1,783,420 | 76.6 kb | Distal (>10kb) Multiome | 761 | |
| chr16:1,826,102–1,827,535 | 120.7 kb | Distal (>10kb) Multiome | 1006 | |
| chr16:1,918,171–1,918,773 | 212.3 kb | Distal (>10kb) Multiome | 129 | |
| chr16:1,929,283–1,930,271 | 223.6 kb | Distal (>10kb) Multiome | 780 | |
| chr16:1,942,671–1,943,761 | 237.2 kb | Distal (>10kb) Multiome | 750 | |
| chr16:1,958,923–1,960,140 | 253.3 kb | Distal (>10kb) Multiome | 826 | |
| chr16:1,964,300–1,965,434 | 258.7 kb | Distal (>10kb) Multiome | 933 | |
| chr16:1,971,481–1,972,435 | 265.8 kb | Distal (>10kb) Multiome | 1010 | |
| chr16:1,979,111–1,980,324 | 273.2 kb | Distal (>10kb) Multiome | 296 | |
| chr16:1,983,450–1,984,851 | 277.8 kb | Distal (>10kb) Multiome | 917 | |
| chr16:1,989,307–1,993,568 | 286.2 kb | Distal (>10kb) Multiome | 706 | |
| chr16:2,003,882–2,004,348 | 297.9 kb | Distal (>10kb) Multiome | 619 |
Genomic view of the MAPK8IP3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.