MAT2A

methionine adenosyltransferase 2A | MAT-II, MATA2, MATII, SAMS2

The protein encoded by this gene catalyzes the production of S-adenosylmethionine (AdoMet) from methionine and ATP. AdoMet is the key methyl donor in cellular processes. [provided by RefSeq, Jun 2011]

Member of: DE-2 DE-2.2 Developmental clusters: GC4

Biological processes 23 terms

ATP binding (GO:0005524)S-adenosylmethionine biosynthetic process (GO:0006556)S-adenosylmethionine biosynthetic process (GO:0006556)S-adenosylmethionine biosynthetic process (GO:0006556)S-adenosylmethionine biosynthetic process (GO:0006556)cellular response to methionine (GO:0061431)cytosol (GO:0005829)cytosol (GO:0005829)identical protein binding (GO:0042802)methionine adenosyltransferase activity (GO:0004478)methionine adenosyltransferase activity (GO:0004478)methionine adenosyltransferase activity (GO:0004478)methionine adenosyltransferase activity (GO:0004478)methionine adenosyltransferase complex (GO:0048269)methionine adenosyltransferase complex (GO:0048269)methionine adenosyltransferase complex (GO:0048269)nucleus (GO:0005634)positive regulation of TORC1 signaling (GO:1904263)protein binding (GO:0005515)protein complex oligomerization (GO:0051259)protein heterooligomerization (GO:0051291)protein hexamerization (GO:0034214)small molecule binding (GO:0036094)

Expression (TPM)

TFs regulating MAT2A 0 TFs

Transcription factors with Perturb-seq knockdown data for MAT2A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAT2A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to MAT2A

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAT2A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr2:85,255,366–85,256,615	283.0 kb	Distal (>10kb) Multiome	414
chr2:85,285,331–85,285,778	253.6 kb	Distal (>10kb) Multiome	463
chr2:85,327,503–85,328,538	211.1 kb	Distal (>10kb) Multiome	1009
chr2:85,354,014–85,355,224	184.5 kb	Distal (>10kb) Multiome	962
chr2:85,413,587–85,414,333	125.3 kb	Distal (>10kb) Multiome HiCAR	351
chr2:85,418,133–85,419,210	120.6 kb	Distal (>10kb) Multiome HiCAR	885
chr2:85,420,473–85,421,406	118.3 kb	Distal (>10kb) Multiome HiCAR	853
chr2:85,437,445–85,438,463	101.3 kb	Distal (>10kb) Multiome HiCAR	501
chr2:85,455,501–85,456,436	83.3 kb	Distal (>10kb) Multiome HiCAR	268
chr2:85,468,626–85,469,195	70.3 kb	Distal (>10kb) Multiome HiCAR	496
chr2:85,537,623–85,540,152	1.4 kb	Proximal (<10kb) Multiome	1210
chr2:85,546,252–85,547,149	7.3 kb	Proximal (<10kb) Multiome	418
chr2:85,561,042–85,561,982	22.3 kb	Distal (>10kb) Multiome	903
chr2:85,577,411–85,578,045	38.4 kb	Distal (>10kb) Multiome	505
chr2:85,578,935–85,580,041	40.4 kb	Distal (>10kb) Multiome	275
chr2:85,584,249–85,584,853	45.4 kb	Distal (>10kb) Multiome	633
chr2:85,595,068–85,596,226	56.5 kb	Distal (>10kb) Multiome	804
chr2:85,601,954–85,603,493	63.5 kb	Distal (>10kb) Multiome	852
chr2:85,611,558–85,612,589	72.9 kb	Distal (>10kb) Multiome	875
chr2:85,615,831–85,616,609	77.0 kb	Distal (>10kb) Multiome	898
chr2:85,678,904–85,679,599	140.2 kb	Distal (>10kb) Multiome	445
chr2:85,753,145–85,755,032	214.6 kb	Distal (>10kb) Multiome	527
chr2:85,827,451–85,827,914	288.4 kb	Distal (>10kb) Multiome	364

Genome Browser

Genomic view of the MAT2A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.