Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF652. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF652 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF652, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:49,191,794–49,193,465 | 169.5 kb | Distal (>10kb) Multiome | 1177 | |
| chr17:49,223,535–49,224,633 | 138.5 kb | Distal (>10kb) Multiome | 281 | |
| chr17:49,230,380–49,231,209 | 131.4 kb | Distal (>10kb) Multiome | 496 | |
| chr17:49,260,115–49,260,840 | 101.8 kb | Distal (>10kb) Multiome | 480 | |
| chr17:49,361,317–49,363,214 | 94 bp | At TSS Multiome | 873 | |
| chr17:49,371,314–49,372,084 | 9.5 kb | Proximal (<10kb) Multiome | 235 | |
| chr17:49,414,619–49,415,442 | 52.8 kb | Distal (>10kb) Multiome | 829 | |
| chr17:49,486,189–49,486,812 | 124.2 kb | Distal (>10kb) Multiome | 147 | |
| chr17:49,494,780–49,495,773 | 133.0 kb | Distal (>10kb) Multiome | 386 | |
| chr17:49,496,269–49,496,902 | 134.3 kb | Distal (>10kb) Multiome | 440 | |
| chr17:49,497,462–49,497,966 | 135.7 kb | Distal (>10kb) Multiome | 280 | |
| chr17:49,508,179–49,508,962 | 146.3 kb | Distal (>10kb) Multiome | 380 | |
| chr17:49,556,195–49,556,772 | 194.2 kb | Distal (>10kb) Multiome | 636 | |
| chr17:49,567,907–49,568,549 | 205.9 kb | Distal (>10kb) Multiome | 623 | |
| chr17:49,569,780–49,570,501 | 207.9 kb | Distal (>10kb) Multiome | 893 | |
| chr17:49,575,427–49,577,397 | 214.4 kb | Distal (>10kb) Multiome | 657 |
Genomic view of the ZNF652 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.