Enables NAD+ poly-ADP-ribosyltransferase activity; NAD+-protein mono-ADP-ribosyltransferase activity; and enzyme binding activity. Involved in several processes, including positive regulation of canonical Wnt signaling pathway; post-translational protein modification; and regulation of telomere maintenance. Located in nuclear envelope; pericentriolar material; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TNKS2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TNKS2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TNKS2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:91,632,611–91,633,844 | 165.2 kb | Distal (>10kb) Multiome | 874 | |
| chr10:91,745,021–91,745,730 | 53.1 kb | Distal (>10kb) Multiome | 223 | |
| chr10:91,796,266–91,796,794 | 1.6 kb | Proximal (<10kb) | 118 | |
| chr10:91,798,050–91,799,545 | 14 bp | At TSS Multiome | 902 | |
| chr10:91,879,304–91,880,277 | 81.3 kb | Distal (>10kb) Multiome | 134 | |
| chr10:91,883,605–91,884,441 | 85.7 kb | Distal (>10kb) Multiome | 290 | |
| chr10:91,887,103–91,887,953 | 89.0 kb | Distal (>10kb) Multiome | 657 | |
| chr10:91,908,112–91,909,644 | 110.3 kb | Distal (>10kb) Multiome | 944 | |
| chr10:91,923,397–91,924,310 | 125.4 kb | Distal (>10kb) Multiome | 981 | |
| chr10:92,045,582–92,046,227 | 247.5 kb | Distal (>10kb) Multiome | 132 | |
| chr10:92,087,615–92,088,099 | 289.6 kb | Distal (>10kb) Multiome | 401 |
Genomic view of the TNKS2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.